STEVE  KAGEN, M.D.   HIGHLIGHTS
        ACCOMPLISHMENTS
       
        CNN Allergy Consultant  (1995-2002)
       
        Winner of the Environmental Protection Agency's 2005 Children's Environmental Health
               Recognition Award for The Allergy Family Guide textbook and CD-ROM program

        One of the first Wisconsin Allergy Specialists Certified in Diagnostic Laboratory Immunology

        Voted by area physicians as one of the Best Doctors in America
       
        Chairman of the Allergen Standardization Committee of the American Academy of Allergy, Asthma,
               and Immunology

        Winner of the 2004 Public Outreach Award from the American Academy of Allergy, Asthma and                Immunology for The Allergy Family© Guide, a 5th grade allergy and asthma education
               program.

        The only Certified Diagnostic Allergy - Immunology Lab in Northeastern Wisconsin


        ALLERGY   RESEARCH
        *  U.S. Patent for the discovery of a worldwide Dust Mite Allergen

        *  Standardized Vaccines used in Allergen Immunotherapy
        *  Developed a new Rapid Venom Immunotherapy technique for the treatment of Bee Sting Allergy
       
        *  Discovered and Sequenced Insect Allergens - Asian Lady Beetle, midge (Lake Fly), and the
               caddisfly (River Fly)

        *  First in the World to Clone and Express an allergenic protein in bacteria
        *  The Only Allergy Clinic in America with Polymerized Ragweed and Grass Vaccines
            which were proven to be the safest allergy injection treatments

        *  Discovered Food Allergens in Frog, Buckwheat, Eggplant, Almond, and Spices

        *  Discovered Cross-Reactive Allergens between Food and Natural Rubber Latex Proteins
         
        *  Proved that Helicobacter pylori can cause Hives
       
        *  Discovered a possible cause of Crohn's Disease  (Copepods)

        *  Demonstrated that Mite Vaccines do not contain Prion Proteins   

        *  Daily Pollen and Mold Spore Monitoring of N.E. Wisconsin air since 1992.
CURRICULUM VITAE
STEVEN L. KAGEN, M.D.
CITIZEN / BIRTHPLACE U.S.A.   Neenah, WI
EDUCATION College:                           University of Wisconsin
                                        1972 B.S. Honors
                                        Molecular Biology

Medical School:               University of Wisconsin
                                        School of Medicine
                                        Madison, WI  1972-1976

Internship & Residency:  Internal Medicine
                                        Northwestern University
                                        School of Medicine
                                        Chicago, IL   1976-1979
 
Fellowship:                      Allergy/Immunology
                                        Medical College of Wis.
                                        Milwaukee, WI 1979-1981
BOARD CERTIFICATION American Board of Internal Medicine
       September 1979
American Board of Allergy & Immunology
       October 1981
Diagnostic Laboratory Immunology
       October 1988
UNIVERSITY AFFILIATIONS
 Assistant Clinical Professor
Division of Allergy & Clinical Immunology
Department of Medicine
Medical College of Wisconsin
Milwaukee, WI
PRACTICE LOCATIONS        Appleton, Wisconsin              1981 - Present
Oshkosh, Wisconsin              1981 - Present
Green Bay, Wisconsin           1986 - Present
Fond du Lac, Wisconsin        1990 - Present
Port St. Lucie, Florida            1986 - 1993
PROFESSIONAL SOCIETIES American Academy of Allergy, Asthma & Immunology
American College of Allergy, Asthma & Immunology
Wisconsin Allergy Society
Wisconsin State Medical Society
ACADEMY COMMITTEES      American Academy of Allergy, Asthma & Immunology:
         Insect Allergy Committee
         Latex Allergy Committee
         Aerobiology Committee
         Allergen Standardization Committee, Chairman
BOARD OF DIRECTORS Joint Council of Allergy, Asthma and Immunology
                         1988-1992
CREATIVE PROJECTS Author and Project Director
         “Helpful Hints” on Kleenex Packages.
          (> 2 billion consumer encounters)
 
Author, Project Director
          Allergy Relief Guide
          A 34-page consumer education booklet with a
          distribution of > 50,000 booklets.
 
National Pollen Network®  ( NPN® )
          A national pollen and mold information service with           distributions to television and print media.
 
Aller-Rhythm® allergy test
          Owner; a colorful graphic revealing seasonal allergy           symptoms risks for affected patients.
 
Aeroallergen Animations
          Computer animations of broadcast ready North           American pollens and mold spores.
 
The Allergy Family® Guide
          An interactive educational 5th grade school program           about allergies and asthma.
 
Aeroallergen PhotoLibrary™ of North America
          Interactive CD and Website-based audio and slide
          program focused on airborne allergens.
U.S. PATENT: DUST MITE U.S. patent awarded to Steven L. Kagen, M.D. and R.   Muthiah, PhD, for the discovery and sequencing of the major allergen of the dust mite (L. destructor).  U.S. Patent No. 5,236,834, Allergenic Molecules from Lepidoglyphus Destructor.  Worldwide patent issued in August 1993.
FOX CITIES CHILDREN’S
MUSEUM		 Creative developer of the Allergy Arcade™ in Appleton, Wisconsin - an interactive educational exhibit designed to teach children and parents about the world of allergy and asthma.
CNN ALLERGY CONSULTANT The exclusive source of daily allergy information to CNN from 1995 to 2002, in collaboration with Board Certified Allergy Specialists throughout the United States as part of NPN, the National Pollen Network. 
THE WEATHER CHANNEL Dr. Kagen provided daily national pollen and mold graphics to The Weather Channel, educating the public about the importance of aeroallergens as causes of asthma, sinus headaches, and hay fever.
ALLERNET.COM Creator and owner of Allernet.com® - a website designed to provide the general public with useful allergy and asthma information along with referral services to Certified allergy specialists throughout the United States at: www.allernet.com
DISTINCTIONS In 1988, Dr. Kagen became one of the first physicians in Wisconsin to be Board Certified in Diagnostic Laboratory Immunology.
BEST DOCTOR IN AMERICA Voted by Wisconsin physicians as one of the
“Best Doctors in America”
AWARDS Winner - 1996 Founder's Award
Fox Cities Children's Museum
AWARDS Winner - 2004 Community Outreach Award from the American Academy of Allergy, Asthma and Immunology for The Allergy Family Guide® - a 5th grade allergy and asthma education program.
AWARDS Winner - Environmental Protection Agency’s
2005 Children’s Environmental Health Recognition Award - for The Allergy Family Guide, for “protecting children from environmental risks, fundamental to making the world a healthier place, now and for future generations.”
AWARDS Winner – 2005 Abstract of Distinction
Federation of Clinical Immunology Societies for  “Superior safety of polymerized allergen vaccines:  Zero systemic reactions during 55,000 injections of polymerized ragweed and grass vaccines in 500 allergy patients. Clin Immunol 2005; S1:55.”
AUTHORSHIP: The Aeroallergen PhotoLibrary of North America.
Steve Kagen, M.D., Walter Lewis, PhD, and Estelle Levetin, PhD. 2004
 
Allergy InsideOut®  Steve Kagen, M.D. 2004
 
The Allergy Family® Guide. Steve Kagen, M.D. 2004
PUBLICATIONS
Interleukins 1.   Soluble mediators of cellular immunity: partial
characterization of Blastogenic Factor. 
Honors Thesis, University of Wisconsin, 1972
Marijuana Asthma 2.   Kagen SL, Fink JN, Sohnle P and Kurup VP.  Marijuana smoking as a source of Aspergillus exposure.  In Proceedings of the 37th Annual Meeting of the American Academy of Allergy, March 1981, San Francisco, CA, p. 63.
3.   Kagen SL, Sohnle P, Kurup VP and Fink JN.  Aspergillus: An inhalable contaminant of marijuana.  New England Journal of Medicine.  1981;304:483-84.
Fabric Softener 4.   Kagen SL, Fink JN, Schlueter DP, et al.  Anti-
Induced Asthma static agent as a cause of small airway disease.  In Proceedings of the 37th Annual Meeting of the American Academy of Allergy, March, 1981, San Francisco, CA, P. 30.
Hypersensitivity 5.   Kagen SL, Fink JN, Schlueter DP, Kurup VP,
Pneumonitis and Fruchtman R.  Streptomyces albus: A new cause of hypersensitivity pneumonitis.  J Allergy Clin Immunol.  1981;68:295-99.
Allergic Aspergillosis 6.   Kagen SL, Cohen SH and Kurup VP.  Ketoconazole therapy of allergic bronchopulmonary aspergillosis.  Presented at the International Congress of Allergology and Clinical Immunology.  London, England, 1982.
Diagnostic Allergy 7.   Cohen SH and Kagen SL. Cimetidine and
Skin Testing allergy skin testing.  Annals of Int Med. 1981;96:787.
Fabric Softener Lung 8.   Kagen SL, Schlueter DP, Cohen SH.  Induction
of small airways disease by a fabric softener.
Marijuana Asthma 9.   Kagen SL, Kurup VP, Sohnle PG, and Fink JN.  Marijuana smoking and fungal sensitization, J Allergy Clin Immunol.  1983;71:389-93.
Smoking & Asthma 10.   Kurup VP, Resnick A, Kagen SL, Cohen SH and Fink JN.  Allergic fungi and actinomycetes in smoking materials and their health implications.
Mycopathologia.  1983;82:61-4.
AIDS 11.   Nunnink JC, Wiedmeyer J, Hank J, Kagen SL and Sondel PS.  Characterization of a possible suppressive factor in AIDS.  UCLA AIDS Symposium, Salt Lake City, Utah, 1983.
Insect Allergy 12.   Kagen SL, Yunginger J, and Johnson R.  Lake fly allergy: Incidence of chironomid sensitivity in an atopic population.  In Proceedings of the 40th Annual Meeting of the American Academy of Allergy & Immunology, March, 1984, Chicago, IL.
13.   Kagen SL.  Inhalant insect allergy.  In Monograph on Insect Allergy, 1986; pp 93-102.  (Levine MI and Lockey RF eds).  D. Lambert Associates, Pittsburgh, PA.
Occupational Insect
Allergy & Asthma		 14.   Kagen SL, Yunginger J and Wynn SR. 
Occupational respiratory allergy due to caddisfly aeroallergens.  J Allergy Clin Immunol.  1986;77:169
Insect Allergen
Immunotherapy		 15.   Kagen SL, Yunginger J, Wynn SR and Swanson
MC.  Midge-specific IgE and IgG responses during lake fly desensitization: An open trial.  J Allergy Clin Immunol.  1986;77:140.
16.   Kagen SL.  Inhalant allergy to arthropods: Insects, arachnids, and crustaceans.  Clin Rev Allergy.1990; 8:99-125.
Caddisfly Allergens 17.   Kagen SL, Koshte V, and Aalberse R.  Cross-reactivity of caddisfly-specific IgE antibodies with arthropoda and mollusca.  Allergy Proceedings. 1988;9:289.
Cross-Reactivity 18.   Koshte VL, Kagen SL and Aalberse R.  Cross-reactivity of IgE antibodies to caddisfly with arthropoda and mollusca.  J Allergy Clin Immunol. 84:174-83, 1989.
Cloning of Insect Allergens 19.   Kagen SL and Siebert P.  Cloning of insect aeroallergens: midge hemoglobins.  Allergy Proceedings.  1988;9:281.
Rapid Desensitization
to Venom		 20.   Bernstein D, Mittman RJ, Kagen SL, Korbe BS and Bernstein IL.  Safety and efficacy of rapid venom immunotherapy (RVIT) for treatment of Hymenoptera-sensitive patients.  J Allergy Clin Immunol.  1989;83:227.
Fire Ant Allergy 21.   Kagen SL and Muthiah R.  Fire ant anaphylaxis:
Allergen characterization and partial amino acid sequence of Sol i II and Sol i III.  Ann Allergy.  1990;64:75.
Guidelines for Diagnosis of Occupational Lung Disease 22.   Bush R and Kagen SL.   Guidelines for the preparation and characterization of high molecular weight allergens used for the diagnosis of occupational lung disease.  J Allergy Clin Immunol.  1989;84:814-19.
Rapid Desensitization to Venom 23.   Bernstein D, Mittman RJ, Kagen SL, Korbee L,
Enrione M and Berstein IL.  Clinical and immunologic studies of rapid venom immunotherapy in Hymenoptera-sensitive patients.  J Allergy Clin Immunol. 1989;84:951-59.
Food Allergens: Buckwheat 24.   Muthiah R and Kagen SL.  Food Allergens: Characterization of major buckwheat carbohydrate  dependent allergens.  J Allergy Clin Immunol.  1990;85:151.
Insect Allergens: Hemoglobins 25.   Kagen SL and Muthiah R.  Insect allergens:
Characterization and partial sequencing of a caddisfly hemoglobin.  J Allergy Clin Immunol. 1990;85:152.
Allergy Vaccine Stability 26.   Muthiah R and Kagen SL. Allergens as enzymes:
Degradation of cat and ragweed allergens by house dust
mite allergen extract. J Allergy Clin Immunol.1990;85:151.
Allergy Vaccine Stability 27.   Kagen SL, Isaacson B and Muthiah R. Polymerized
ragweed vaccine: Retention of all epitopes. J Allergy Clin
Immunol. 1991;87:188.
Allergy Vaccine Stability 28.   Knoll R, Kagen SL and Muthiah R. Allergens as
enzymes: Failure of HSA to protect degradation of grass
allergens by mold extracts. J Allergy Clin Immunol.
1991;87:188.
Barn Allergy: Storage Mite Allergens 29.   Muthiah R, Miller M and Kagen SL. Barn
allergy: Isolation and characterization of the major
allergens of storage mites: L. destructor. J Allergy Clin
Immunol. 1991;87:326.
Insect Allergy 30.   Baur X, Liebers V, Mazur G, Becker WM, Kagen SL,
Kawai K. Immunologic cross-reactivity of hemoglobins
in the Diptera family Chironomidae. Allergy
1991;46:445051.
Fire Ant Allergy 31.   Knoll R, Kagen S and Muthiah R. Non-specific
reactivity of fire ant whole body extract in the diagnosis
of fire ant allergy. J Allergy Clin Immunol. 1992;89:51.
Immunization Screen 32.   Muthiah R, Kagen S, Hildeman D and Knoll R. New
Immunization screen reveals under-immunization of
patients attending allergy & asthma clinics. J Allergy
Clin Immunol. 1992;89:490.
Protective Levels to
Fire Ant Venom		 33.   Kagen S, Muthiah R, Hildeman D, Knoll R and
Friedman S. Fire ant anaphylaxis: Initial determination
of fire ant-specific IgG anti-toxin levels. J Allergy Clin
Immunol. 1992;89:716.
Allergen Immunotherapy 34.   Kagen SL. Other indications for administration of
allergy immunotherapy: Insects, fire ants and
therapeutic agents. Immunology and Allergy Clinics of
North America. 1992;12:177-97.
Rapid Venom Immunotherapy 35.   Bernstein JA, Kagen SL, Bernstein DI and Bernstein IL.
An extended experience indicating that rapid venom
immunotherapy (RVIT) is safe for treatment of
Hymenoptera (Hym) anaphylaxis. J Allergy Clin
Immunol. 1993;91:563.
Polymerized Midge AllergenImmunotherapy 36.   Knoll R, Kagen SL, Muthiah R and Hildeman.
Polymerized midge allergen immunotherapy (PMAIT):
clinical reduction in early and late phase reactivity and
prevention of rhinitis and asthma morbidity. J Allergy
Clin Immunol. 1994;93:251.
Polymerized Grass AllergenImmunotherapy 37.   Hildeman D, Muthiah R and Kagen SL.
Successful polymerized grass allergen immunotherapy
(PGAIT): failure of in vitro measurements to correlate
with clinical outcomes. J Allergy Clin Immunol.
1994;93:251.
Polymerized Ragweed AllergenImmunotherapy 38.   Hempel D, Muthiah R, Hildeman D and Kagen SL.
Polymerized ragweed allergen immunotherapy
(PRAIT): failure of anti-idiotypic antibody (AIA) to
predict clinical outcomes. J Allergy Clin Immunol.
1994;93:251.
Helicobacter Pylori 39.   Zondlo J, Muthiah R, Knoll R and Kagen SL.
Helicobacter pylori (Hp): a new cause of urticaria (U)
and exercise-induced anaphylaxis (EIA) ó identification
of Hp allergens. J Allergy Clin Immunol. 1994;93:220.
Allergen Extract Stability 40.   Kagen SL, Muthiah R and Knoll R. Allergens as
enzymes: a two year study of aqueous allergen extract
stability and the deleterious effect of mixing allergen
extracts together. J Allergy Clin Immunol. 1994;93:253.
Frog-induced Anaphylaxis 41.   Muthiah R, Kagen SL and Hempel D. Frog-induced
anaphylaxis (ANA): isolation and characterization of
the major frog allergen, which is cross-reactive with
cod parvalbumin. J Allergy Clin Immunol. 1994;93:209.
Rapid Venom Immunotherapy 42.   Bernstein JA, Kagen SL, Bernstein DI and Bernstein
LB. Rapid venom immunotherapy is safe for routine
use in the treatment of patients with Hymenoptera
anaphylaxis. Annals of Allergy Asthma Immunol.
1994;73:423-8.
Flaxseed-Induced Anaphylaxis 43.   Muthiah R, Louthain L, Knoll R and Kagen S.
Flaxseed-induced anaphylaxis (ANA): another cross-
reactive carbohydrate food allergen. J Allergy Clinic
Immunol. 1995;95:370.
Helicobacter pylori 44.   Kagen S, Zondlo A, Zondlo J and Muthiah R.
Helicobacter pylori and allergic disease:
characterization of Helicobacter allergens. J Allergy
Clin Immunol. 1995;95:255.
Insect Allergy 45.   Kagen SL and Chapman M. Allergy to inhalants of
arthropods: insects and arachnids. In Monograph on
Insect Allergy. 1995;95:370. (Levine MI and Lockey
RF eds). D. Lambert Associates, Pittsburgh, PA.
Eggplant Anaphylaxis 46.   Muthiah R, Zondlo A, Zondlo J and Kagen S. Eggplant
anaphylaxis: isolation of the major allergens and
demonstration of cross-reactivity with other
Solanaceae. J Allergy Clin Immunol. 1996;97:334.
Aerobiology 47.   Kagen S, Muthiah R, Knoll R, Graphos G and DeStasio
B. Aerobiology: Grass pollen forecasting models. J
Allergy Clin Immunol. 1996;97:217.
Mannose Binding Protein Deficiency 48.   Kagen S, Muthiah R and Slupianek J. Mannose
binding protein deficiency is more frequent than IgA
deficiency. J Allergy Clin Immunol. 1997;99:S396
Allergy to Acacia in Synthroid 49.   Muthiah R, Kagen S, Zondlo A and Zondlo J. Hidden
allergens in medications: Allergy to acacia in Synthroid
tablets. J Allergy Clin Immunol. 1997;99:S492.
Latex & Food Anaphylaxis 50.   Kagen SL and Muthiah R. Latex and Food induced
Anaphylaxis: Oregano, Dill, Sage and Carrot Cross-
React with Natural Rubber Latex. J Allergy Clin
Immunol. 1998;101:S208.
Chinchilla Allergy 51.   Muthiah R, Yablon B, Reddy, and Kagen S. Chinchilla
Allergy: A new Cause of Animal Hypersensitivity.
J Allergy Clin Immunol. 1999;103:93.
Anaphylaxis to PPD 52.   Kagen S and Muthiah R. Anaphylaxis to PPD:
Tuberculosis Skin Test Antigen Atopy. J Allergy Clin
Immunol. 1999;103:149.
Almonds and Latex Allergy 53.   Kagen SL and Muthiah R. Latex, Almond and
Tobacco: Cross-Reactive Allergens. Annals Allergy,
Asthma Immunol. 2000;84:146
Latex and Ginger Cross-React 54.   Muthiah R, Peterson A and Kagen SL. Latex and
Ginger Allergy. Annals Allergy, Asthma Immunol.
2000;84:168.
Ladybug Allergy 55.   Kagen SL and Muthiah R. Ladybugs: A New Cause of
Allergy. Annals Allergy, Asthma Immunol. 2000;84:146.
Caddisfly Allergens 56.   Muthiah R, Ptachinski K, Ludden D, Kagen SL Insect
Allergens: Isolation of Caddisfly Allergens.
J Allergy Clin Immunol. 2001;107:S14.
Kombu Anaphylaxis 57.   Zondlo J, Muthiah R, Kagen S and Kagen M. Kombu
Induced Anaphylaxis. Annals Allergy Asthma Immunol.
2002;88:118.
Ragweed Pollen 58.   Muthiah R and Kagen S. Ragweed Pollen in the
Spring Air. Annals Allergy Asthma Immunol.
2003;90:115.
Leaf Mites 59.   Muthiah R, Arlian L and Kagen S. Leaf Mites: Viable
Sources of Outdoor Aeroallergens. Annals of Allergy.
2003;90:115.
Ladybug Allergens 60.   Muthiah R and Kagen S. Ladybug Allergy: Sequence
of a Major Asian Beetle Allergen. Annals of Allergy
Asthma Immunol. 2003;90:100.
Copepod Allergens 61.   Kagen S, Muthiah R and Breteler K. Copepods: A
New Worldwide Source of Allergens. Annals of Allergy
Asthma Immunol. 2003;90:96.
Slim-Fast® Allergy 62.   Muthiah R and Kagen S. Anaphylaxis induced by Slim-
Fast: The perils of weight lost in two patients. Annals
of Allergy Asthma Immunol. 2004;92:P48.
Poisonous Snake Venom 63.   Kagen S and Muthiah R. Poisonous Snake Venom
Anaphylaxis vaccination: A case report of a non-
physician directed experiment. Annals of Allergy
Asthma Immunol. 2004;92:72.
Midge Allergen Anaphylaxis 64.   Gutin F, Kagen S, Muthiah R, Bahrainwala A. Severe
protracted anaphylaxis to midge allergen in a 4 YO
boy. Annals of Allergy Asthma Immunol.
2004;92:P171.
Allergen Extract Stability 65.   Kagen S, Muthiah R, Holinbeck J. A new and safer
method for preserving allergen stability in human
vaccines. J Allergy Clin Immunol. 2004;113;S110P.
Prion Proteins in Vaccines 66.   Kagen S, O’Rourke K, Muthiah R, and Arlian LG.
Prion proteins in vaccines intended for human use -
mites, human serum albumin and mite colony feeds:
No evidence of prion presence. Annals of Allergy
Asthma Immunol. 2005; 94:175.
“Breakfast Square” Anaphylaxis 67.   Kagen S and Muthiah R. Anaphylaxis associated with
eating a Breakfast Square product. In press.
Partial Sequences of Copepod-
Derived Protein Antigens		 68.   Muthiah R, Kagen S and Burton RS. Copepods:
Worldwide sources of allergens - partial sequences of
three unique proteins. J Allergy Clin Immunol 2005;
115:S91.
Superior Safety of PolymerizedAllergen Vaccines 69.   Kagen S, Zondlo J, Muthiah R and Kagen M.
Superior safety of polymerized allergen vaccines:
Zero systemic reactions during 55,000 injections of
polymerized ragweed and grass vaccines in 500
allergy patients. 2005. Clin Immunol 2005; S1:55.